Madonna Center is a San Antonio nonprofit providing education, childcare, family assistance, senior services, and community resources to children, adults, and families, with a special focus on supporting residents of San Antonio's West Side. They help families overcome barriers associated with poverty by providing practical assistance, education, resource connections, and programs that strengthen children, parents, and older adults.

Madonna Center provides childcare and educational programs for children from infancy through age 12. Early childhood education helps young children develop skills needed for school, while after-school and summer programs provide supervised learning, recreation, enrichment, and social activities. The Home Instruction for Parents of Preschool Youngsters (HIPPY) program helps parents become their child's first teacher. Families receive books, activities, and a school-readiness curriculum covering areas such as math, science, language, and literacy.

Seniors age 60 and older can participate in nutritious meal programs, recreational activities, social interaction, and activities designed to support physical and mental well-being. Through social services and community partnerships, Madonna Center helps families connect with basic necessities and additional community resources when they are experiencing financial or personal challenges.