Street medicine is the provision of patient-centered, reality-based healthcare outside the traditional clinical setting. It can be thought of as an old-fashioned house call where the roof over someone’s head might be a bridge, a tarp, a tent, the canopy of trees, or the open sky. There are no refrigerators to store medications. No running water to keep wounds clean or attend to personal hygiene needs. No easy access to transportation, making trips to clinics and pharmacies difficult or impossible.Due to the austere conditions and realities of street life, street medicine efforts cannot provide comprehensive care to our unsheltered friends; rather, teams aim to build meaningful relationships by caring for acute needs of patients where they live and coordinating more robust care in the community for issues outside the scope of a street medicine practice.